Inflammation / Resolution
Why can inflammatory programs persist after molecular correction?
We examine residual inflammatory states in human disease using molecular profiling anchored to clinical phenotype.
Clinical Omics & Inflammation Biology
Measure what changes.
Understand what persists.
From clinical phenotype to molecular mechanism.
We integrate patient-derived samples with lipidomics, metabolomics and experimental biology to investigate inflammation, resolution and clinically meaningful molecular states.
Molecular signal / clinical context
LipidomicsMetabolomicsResolution
Clinical phenotypeMetabolic stateInflammationResolution
Omics are not the endpoint. They are a way to connect what we measure in patients with the biology that drives disease.
Research focus
Three molecular lenses. One biological question: what shapes inflammatory disease?
01Lipidomics
Inflammation & resolution
Profiling lipid mediator networks that accompany initiation, persistence and resolution of inflammation.
02MetabolomicsClinical metabolic states
Mapping metabolite signatures in patient-derived samples and linking them to defined clinical phenotypes.
03TranslationFrom association to mechanism
Integrating molecular readouts with pharmacology and experimental models to build testable biological hypotheses.
How we work
Clinical context first. Molecular depth second. Mechanism always.
Our workflow starts with a precise clinical question, not with a technology. Samples, analytical platforms and experimental systems are selected around the biological problem.
01
Define
Patients, phenotype and the clinical question.
02
Measure
Lipidomic, metabolomic and complementary molecular readouts.
03
Integrate
Molecular features with clinical and inflammatory phenotypes.
04
Test
Mechanisms that can be challenged experimentally.
Selected programs
Human disease, studied close to the patient and deep into the mechanism.
Exposure / Response
Local drug exposure and molecular response.
We study how airway-proximal pharmacology can inform treatment response and clinical biology.
Research lead
Matteo Mucci
Clinical Omics & Inflammation Biology
The laboratory works at the interface of human samples, analytical chemistry and experimental biology, with the aim of turning molecular signatures into biologically testable questions.