Residual inflammation
Which inflammatory states persist despite effective CFTR modulation?
Program 01
CF & Airway Biology
Residual airway inflammation and resolution biology in the era of CFTR modulators.
Cystic fibrosis
What remains after CFTR correction?
Highly effective CFTR modulators have transformed cystic fibrosis care, but molecular correction does not necessarily erase every downstream inflammatory program. We study residual airway inflammation using patient-derived samples, clinical phenotyping and molecular profiling.
Resolution
Are pro-resolving lipid pathways restored, incompletely engaged or uncoupled from clinical improvement?
Heterogeneity
Why do people receiving the same therapy show different molecular and clinical responses?