Signals of activation
Quantifying lipid pathways associated with initiation and propagation of inflammation.
Molecular layer
Lipidomics
Inflammatory and pro-resolving lipid mediators as dynamic readouts of immune state.
Lipid mediator biology
Read inflammation as a dynamic biochemical program.
Lipidomics allows us to study the balance between inflammatory signaling and the endogenous pathways that actively terminate inflammation. We focus on clinically relevant samples and integrate lipid mediator profiles with disease state and treatment response.
Signals of recovery
Profiling specialized pro-resolving mediators and related pathways involved in restoring tissue homeostasis.
Phenotype-linked profiles
Relating lipid mediator patterns to clinical status, treatment exposure and functional outcomes.
From signature to function
Using focused experimental systems to test candidate pathways identified in human samples.